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Clinical Trial
. 2006 Apr 11;66(7):1117-9.
doi: 10.1212/01.wnl.0000204235.81272.e2.

Randomized controlled phase II trial of glatiramer acetate in ALS

P H Gordon  1 , C Doorish, J Montes, R L Mosley, B Diamond, R B Macarthur, L H Weimer, P Kaufmann, A P Hays, L P Rowland, H E Gendelman, S Przedborski, H Mitsumoto
Affiliations
Clinical Trial

Randomized controlled phase II trial of glatiramer acetate in ALS

P H Gordon et al. Neurology. .

Erratum in

  • Neurology. 2006 Sep 12;67(5):920. Mosely, R L [corrected to Mosley, RL]

Abstract

The authors conducted a randomized controlled trial to test the safety and immunology of glatiramer acetate in ALS. Twenty treated patients were randomly assigned to daily or biweekly injections. Ten control patients were selected from another trial and followed up concurrently. Injection reactions were the only common adverse event (p = 0.01). Treated patients showed enhanced lymphocyte proliferation (p = 0.02). The safety profile and immune effects support conducting larger trials of dose selection and efficacy.

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