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. 2006 Apr;6(4):669-76.
doi: 10.1021/nl052405t.

Peptide-labeled near-infrared quantum dots for imaging tumor vasculature in living subjects

Weibo Cai  1 , Dong-Woon Shin, Kai Chen, Olivier Gheysens, Qizhen Cao, Shan X Wang, Sanjiv S Gambhir, Xiaoyuan Chen
Affiliations

Peptide-labeled near-infrared quantum dots for imaging tumor vasculature in living subjects

Weibo Cai et al. Nano Lett. 2006 Apr.

Abstract

We report the in vivo targeting and imaging of tumor vasculature using arginine-glycine-aspartic acid (RGD) peptide-labeled quantum dots (QDs). Athymic nude mice bearing subcutaneous U87MG human glioblastoma tumors were administered QD705-RGD intravenously. The tumor fluorescence intensity reached maximum at 6 h postinjection with good contrast. The results reported here open up new perspectives for integrin-targeted near-infrared optical imaging and may aid in cancer detection and management including imaging-guided surgery.

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