Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2006 Aug;253(8):1060-3.
doi: 10.1007/s00415-006-0162-7. Epub 2006 Apr 11.

Rapid improvement in cortical neuronal integrity in amyotrophic lateral sclerosis detected by proton magnetic resonance spectroscopic imaging

Sanjay Kalra  1 , Peter Tai, Angela Genge, Douglas L Arnold
Affiliations

Rapid improvement in cortical neuronal integrity in amyotrophic lateral sclerosis detected by proton magnetic resonance spectroscopic imaging

Sanjay Kalra et al. J Neurol. 2006 Aug.

Abstract

Riluzole prolongs survival in amyotrophic lateral sclerosis. The temporal and spatial profile of its effect on the brain is unknown. We used proton magnetic resonance spectroscopic imaging to evaluate the neuronal response to 1 day of riluzole treatment in motor and non-motor regions of the brain. In 10 patients the N-acetylaspartate/total creatine (NAA/Cr) ratio increased in the precentral gyrus and supplementary motor area, but not in the post-central gyrus or parietal lobe. Improvement in cortical neuronal metabolic function in the motor cortex occurs early with riluzole treatment.

PubMed Disclaimer

References

    1. Lancet. 1995 Jan 7;345(8941):60-1 - PubMed
    1. J Neurosci. 1996 Oct 1;16(19):6125-33 - PubMed
    1. J Neurochem. 2001 Apr;77(1):347-50 - PubMed
    1. Ann Neurol. 2001 Apr;49(4):536-9 - PubMed
    1. Neuroreport. 1998 Jun 1;9(8):1757-61 - PubMed

Publication types

LinkOut - more resources