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. 2006 Apr 14;12(14):2288-90.
doi: 10.3748/wjg.v12.i14.2288.

Assay of gastrin and somatostatin in gastric antrum tissues of children with chronic gastritis and duodenal ulcer

Xiao-Zhi Xie  1 , Zhi-Guang Zhao, Dan-Si Qi, Zong-Min Wang
Affiliations

Assay of gastrin and somatostatin in gastric antrum tissues of children with chronic gastritis and duodenal ulcer

Xiao-Zhi Xie et al. World J Gastroenterol. .

Abstract

Aim: To study the expressions of gastrin (GAS) and somatostatin (SS) in gastric antrum tissues of children with chronic gastritis and duodenal ulcer and their role in pathogenic mechanism.

Methods: Specimens of gastric antrum mucosa from 83 children were retrospectively analyzed. Expressions of GAS and SS in gastric antrum tissues were assayed by the immunohistochemical En Vision method.

Results: The expressions of GAS in chronic gastritis Hp+ group (group A), chronic gastritis Hp-group (group B), the duodenal ulcer Hp+group (group C), duodenal ulcer Hp-group (group D), and normal control group (group E) were 28.50+4.55, 19.60+2.49, 22.69+2.71, 25.33+4.76, and 18.80+2.36, respectively. The value in groups A-D was higher than that in group E. The difference was not statistically significant. The expressions of SS in groups A-E were 15.47+1.44, 17.29+2.04, 15.30+1.38, 13.11+0.93 and 12.14+1.68, respectively. The value in groups A-D was higher than that in group E. The difference was also not statistically significant.

Conclusion: The expressions of GAS and SS are increased in children with chronic gastritis and duodenal ulcer.

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Figures

Figure 1
Figure 1
Helicobacter pylori in gastric pit (Giemasa ×400).
Figure 2
Figure 2
Expression of GAS (A) and SS (B) in glands. Brown particles were identified in cytoplasm (En Vision ×400).
See this image and copyright information in PMC

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References

    1. Haruma K, Sumii K, Okamoto S, Yoshihara M, Sumii M, Kajiyama G, Wagner S. Helicobacter pylori infection is associated with low antral somatostatin content in young adults. Implications for the pathogenesis of hypergastrinemia. Scand J Gastroenterol. 1995;30:550–553. - PubMed
    1. Levi S, Beardshall K, Haddad G, Playford R, Ghosh P, Calam J. Campylobacter pylori and duodenal ulcers: the gastrin link. Lancet. 1989;1:1167–1168. - PubMed
    1. Dawes C, O'Connor AM, Aspen JM. The effect on human salivary flow rate of the temperature of a gustatory stimulus. Arch Oral Biol. 2000;45:957–961. - PubMed
    1. Calam J. The somatostatin-gastrin link of Helicobacter pylori infection. Ann Med. 1995;27:569–573. - PubMed
    1. Sumii K, Sumioka M, Yoshihara M, Tari A, Haruma K, Kajiyama G. Somatostatin in gastric juice in normal subjects and patients with duodenal ulcer. Dig Dis Sci. 1992;37:1020–1024. - PubMed