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. 2006 Apr 14;12(14):2288-90.
doi: 10.3748/wjg.v12.i14.2288.

Assay of gastrin and somatostatin in gastric antrum tissues of children with chronic gastritis and duodenal ulcer

Xiao-Zhi Xie  1 , Zhi-Guang Zhao, Dan-Si Qi, Zong-Min Wang
Affiliations

Assay of gastrin and somatostatin in gastric antrum tissues of children with chronic gastritis and duodenal ulcer

Xiao-Zhi Xie et al. World J Gastroenterol. .

Abstract

Aim: To study the expressions of gastrin (GAS) and somatostatin (SS) in gastric antrum tissues of children with chronic gastritis and duodenal ulcer and their role in pathogenic mechanism.

Methods: Specimens of gastric antrum mucosa from 83 children were retrospectively analyzed. Expressions of GAS and SS in gastric antrum tissues were assayed by the immunohistochemical En Vision method.

Results: The expressions of GAS in chronic gastritis Hp+ group (group A), chronic gastritis Hp-group (group B), the duodenal ulcer Hp+group (group C), duodenal ulcer Hp-group (group D), and normal control group (group E) were 28.50+4.55, 19.60+2.49, 22.69+2.71, 25.33+4.76, and 18.80+2.36, respectively. The value in groups A-D was higher than that in group E. The difference was not statistically significant. The expressions of SS in groups A-E were 15.47+1.44, 17.29+2.04, 15.30+1.38, 13.11+0.93 and 12.14+1.68, respectively. The value in groups A-D was higher than that in group E. The difference was also not statistically significant.

Conclusion: The expressions of GAS and SS are increased in children with chronic gastritis and duodenal ulcer.

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Figures

Figure 1
Figure 1
Helicobacter pylori in gastric pit (Giemasa ×400).
Figure 2
Figure 2
Expression of GAS (A) and SS (B) in glands. Brown particles were identified in cytoplasm (En Vision ×400).
See this image and copyright information in PMC

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