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Review
. 2006 Apr;73(4):390-7.
doi: 10.3949/ccjm.73.4.390.

Do thiazolidinediones cause heart failure? A critical review

W H Wilson Tang  1
Affiliations
Free article
Review

Do thiazolidinediones cause heart failure? A critical review

W H Wilson Tang. Cleve Clin J Med. 2006 Apr.
Free article

Erratum in

  • Cleve Clin J Med. 2006 Jun;73(6):588

Abstract

Concern has been raised about whether the fluid retention caused by thiazolidinediones (TZDs, ie, rosiglitazone and pioglitazone) can cause or exacerbate congestive heart failure. Although fluid retention is a worrisome side effect of TZDs, current evidence does not link fluid retention caused by TZDs with worsening heart function. TZDs have many benefits for patients with diabetes and can even be used cautiously in patients with mild heart failure, with careful monitoring of volume status.

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Comment in

  • Thiazolidinediones and heart failure.
    Jaderholm PL. Jaderholm PL. Cleve Clin J Med. 2006 Jun;73(6):587; author reply 587-8. doi: 10.3949/ccjm.73.6.587. Cleve Clin J Med. 2006. PMID: 16784160 No abstract available.

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