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Case Reports
. 2006 Apr;81(4):545-8.
doi: 10.4065/81.4.545.

Variant angina associated with bitter orange in a dietary supplement

Christopher A Gange  1 , Christopher Madias, Erika M Felix-Getzik, Andrew R Weintraub, N A Mark Estes 3rd
Affiliations
Case Reports

Variant angina associated with bitter orange in a dietary supplement

Christopher A Gange et al. Mayo Clin Proc. 2006 Apr.

Abstract

The Food and Drug Administration has banned the sale of ephedrine-based weight-loss products because of their association with many cardiovascular adverse effects. Bitter orange is now being used as a stimulant in "ephedra-free" weight-loss supplements but was recently implicated in adverse cardiovascular sequelae. To our knowledge, this report describes the first case of variant angina associated with bitter orange in a dietary supplement.

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