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. 2006 Apr;33(2):117-22.
doi: 10.1111/j.1744-313X.2006.00581.x.

Genetic analysis of HLA, NA and HPA typing in type 2 diabetes and ASO

S Nomura  1 , A Shouzu, S Omoto, T Matsuzaki, M Yamaoka, M Abe, M Hosokawa, M Nishikawa, T Iwasaka, S Fukuhara
Affiliations

Genetic analysis of HLA, NA and HPA typing in type 2 diabetes and ASO

S Nomura et al. Int J Immunogenet. 2006 Apr.

Abstract

We examined the genetic status of human leucocyte antigens (HLA), human platelet alloantigens (HPA) and neutrophil-specific antigens (NA) in patients with type 2 diabetes mellitus and diabetic arteriosclerosis obliterans (ASO). To our knowledge, the present study is the first report showing the relationship among three genetic factors in type 2 diabetes mellitus and ASO patients. HLA typing was performed by the polymerase chain reaction (PCR)-restriction fragment length polymorphism method. HPA-typing and NA-typing were by a PCR-sequence-specific primer method. The incidence of HLA-DRB1*1501 was found to be significant in type 2 diabetes and non-diabetic, particularly ASO-positive patients, compared to control subjects. There were no differences in NA1/NA2 between the control and diabetic or non-diabetic ASO groups. However, the frequency of NA2/NA2 in ASO-positive diabetes and non-diabetic ASO patients was significantly higher than controls. The a/b genotype of HPA-5a/5b was significantly lower in type 2 diabetes and non-diabetic ASO-positive patients than in controls. These findings suggest that genetic studies of HLA, NA and HPA could be useful to understand the pathogenesis of type 2 diabetes and ASO.

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Figure 1
Figure 1
Relative frequencies of HLA-DRB1*1501 in type 2 diabetes and ASO patients. N.S. not significant.
See this image and copyright information in PMC

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