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. 2006 May;27(10):1174-81.
doi: 10.1093/eurheartj/ehi879. Epub 2006 Apr 12.

Uric acid and inflammatory markers

Carmelinda Ruggiero  1 , Antonio Cherubini, Alessandro Ble, Angelo J G Bos, Marcello Maggio, Vishwa D Dixit, Fulvio Lauretani, Stefania Bandinelli, Umberto Senin, Luigi Ferrucci
Affiliations

Uric acid and inflammatory markers

Carmelinda Ruggiero et al. Eur Heart J. 2006 May.

Abstract

Aims: The role of uric acid (UA) in the process of atherosclerosis and atherotrombosis is controversial. Epidemiological studies have recently shown that UA may be a risk factor for cardiovascular diseases and a negative prognostic marker for mortality in subjects with pre-existing heart failure.

Methods and results: We evaluate a relationship between UA levels and several inflammatory markers in 957 subjects, free of severe renal failure, from a representative Italian cohort of persons aged 65-95. Plasma levels of UA and white blood cell (WBC) and neutrophil count, C-reactive protein, interleukin-1 receptor antagonist (IL-1ra), interleukin-6 (IL-6), soluble IL-6 receptor (sIL-6r), interleukin-18 (IL-18), and tumor necrosis factor-alpha (TNF-alpha) were measured. Complete information on potential confounders was collected using standard methods. WBC (P=0.0001), neutrophils (P<0.0001), C-reactive protein (P<0.0001), IL-1ra (P<0.0001), IL-6 (P=0.0004), sIL-6r (P=0.002), IL-18 (P<0.0001), TNF-alpha (P=0.0008), and the percentage of subjects with abnormally high levels of C-reactive protein (P=0.004) and IL-6 (P=<0.0001) were significantly higher across UA quintiles. After adjustment for age, sex, behaviour- and disease-related confounders, results were virtually unchanged. In subjects with UA within the normal range, UA was significantly and independently associated with neutrophils count, C-reactive protein, IL-6, IL-1ra, IL-18, and TNF-alpha, whereas non-significant trends were observed for WBC (P=0.1) and sIL-6r (P=0.2).

Conclusion: A positive and significant association between UA and several inflammatory markers was found in a large population-based sample of older persons and in a sub-sample of participants with normal UA. Accordingly, the prevalence of abnormally high levels of C-reactive protein and IL-6 increased significantly across UA quintiles.

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Conflict of interest statement

Conflict of interest: none declared.

Figures

Figure 1
Figure 1
Prevalence of subjects with high levels of neutrophils, IL-6, and CRP according to uric acid quintiles.
Figure 2
Figure 2
Mean values of inflammatory parameters, (expressed as a number of SD from the population mean), according to uric acid quintiles.
See this image and copyright information in PMC

Comment in

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