Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2006 Jul;32(3):489-97.
doi: 10.1093/schbul/sbj069. Epub 2006 Apr 12.

Cognitive function and symptoms in adolescents with schizotypal personality disorder

Hanan Trotman  1 , Amanda McMillan, Elaine Walker
Affiliations

Cognitive function and symptoms in adolescents with schizotypal personality disorder

Hanan Trotman et al. Schizophr Bull. 2006 Jul.

Abstract

Cognitive deficits have been documented in schizophrenia and spectrum disorders. This study examines cognitive functioning and its relation to symptoms in adolescents with schizotypal personality disorder (SPD). Participants are 89 adolescents recruited for a study of youth at risk for Axis I disorders, especially psychosis. At intake, 34 met criteria for SPD, 38 for another Axis II disorder and/or conduct disorder (Other disorder-OD), and 17 did not currently meet criteria for any DSM-IV disorder (normal control-NC). At initial assessment, cognitive functioning was measured using subtests from the Wechsler Intelligence Scales and Wechsler Memory Scales (WMS), and symptoms were measured using the Structured Interview for Prodromal Symptoms (SIPS). At the time of this report, 50 were readministered the SIPS at 1-year follow-up (T2). The SPD group scored significantly below the NC group on the Arithmetic subtest of the Wechsler Intelligence Scales, but there was only limited evidence of group differences on the WMS. Poorer performance on the Wechsler Intelligence Scales was associated with greater severity of negative and disorganized symptoms. Deficits on the WMS were linked with more severe disorganized symptoms. The findings reported here are consistent with previous reports of limited cognitive deficits in adolescents with SPD, with the most marked deficits in mental arithmetic. The associations between symptoms and cognitive scores parallel those observed in adults with schizophrenia and spectrum disorder, and they are consistent with the notion that negative symptoms are more stable and partially reflect premorbid cognitive functions.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Mean (SD error bars) Symptom Scores by Diagnostic Group.
Fig. 2
Fig. 2
Mean (SD error bars) Intellectual Subtest Scores by Diagnostic Group.
Fig. 3
Fig. 3
Mean (SD error bars) Wechsler Memory Scales Subtest Scores by Diagnostic Group.
See this image and copyright information in PMC

References

    1. Ang YG, Tan HY. Academic deterioration prior to first episode schizophrenia in young Singaporean males. Psychiatry Res. 2004;121:303–307. - PubMed
    1. Fuller R, Nopoulos P, Arndt S, O'Leary D, Ho BC, Andreasen NC. Longitudinal assessment of premorbid cognitive functioning in patients with schizophrenia through examination of standardized scholastic test performance. Am J Psychiatry. 2002;159:1183–1189. - PubMed
    1. Lencz T, Smith CW, Auther A, Correll CU, Cornblatt B. Nonspecific and attenuated negative symptoms in patients at clinical high-risk for schizophrenia. Schizophr Res. 2004;68:37–48. - PubMed
    1. Walker EF, Grimes KE, Davis DM, Smith AJ. Childhood precursors of schizophrenia: facial expressions of emotion. Am J Psychiatry. 1993;150:1654–1660. - PubMed
    1. Yung AR, Phillips LJ, Yuen HP, McGorry PD. Risk factors for psychosis in an ultra high-risk group: psychopathology and clinical features. Schizophr Res. 2004;67:131–142. - PubMed

Publication types