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Review
. 2006 May;7(5):335-46.
doi: 10.1038/nrm1907.

The multifaceted mismatch-repair system

Josef Jiricny  1
Affiliations
Review

The multifaceted mismatch-repair system

Josef Jiricny. Nat Rev Mol Cell Biol. 2006 May.

Abstract

By removing biosynthetic errors from newly synthesized DNA, mismatch repair (MMR) improves the fidelity of DNA replication by several orders of magnitude. Loss of MMR brings about a mutator phenotype, which causes a predisposition to cancer. But MMR status also affects meiotic and mitotic recombination, DNA-damage signalling, apoptosis and cell-type-specific processes such as class-switch recombination, somatic hypermutation and triplet-repeat expansion. This article reviews our current understanding of this multifaceted DNA-repair system in human cells.

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