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Comparative Study
. 1991 Nov;82(11):1175-7.
doi: 10.1111/j.1349-7006.1991.tb01774.x.

Induction of signet ring cell carcinomas in X-irradiated hypocatalasemic mice (C3H/Cbs)

H Watanabe  1 , P O Ogundigie, T Takahashi, T Ishimoto, A Ito
Affiliations
Comparative Study

Induction of signet ring cell carcinomas in X-irradiated hypocatalasemic mice (C3H/Cbs)

H Watanabe et al. Jpn J Cancer Res. 1991 Nov.

Abstract

The stomach region of hypocatalasemic mice of both sexes was X-irradiated once with a dose of 20 Gy. Thirteen months after the irradiation, 3 out of 13 (20%) males and 2 out of 9 (15%) females were observed to have developed signet ring cell carcinomas in the glandular stomach. This finding was statistically significant (P less than 0.01 in males and P less than 0.05 in females) compared to a total absence of similar tumors in the non-irradiated controls. Local invasion of malignant tumors into muscle and subserosal layers was observed, but no metastatic tumors were found in distant organs.

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