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Review
. 2006 Apr 15;332(7546):895-8.
doi: 10.1136/bmj.332.7546.895.

Understanding the NSAID related risk of vascular events

Harald E Vonkeman  1 , Jacobus R B J Brouwers, Mart A F J van de Laar
Affiliations
Review

Understanding the NSAID related risk of vascular events

Harald E Vonkeman et al. BMJ. .
No abstract available

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Figures

Figure 1
Figure 1
Merck withdrew Vioxx in 2004 Credit: AMY SANCETTA/EMPICS
Fig 1
Fig 1
Differential prostanoid synthesis, showing differential prostanoid synthesis by different cells in different tissues. NSAIDs' anti-inflammatory effects are due to cyclo-oxygenase-2 (COX 2) inhibition, and adverse effects occur because of COX 1 and also COX 2 inhibition
Fig 2
Fig 2
Inhibition of cyclo-oxygenase-1 (COX 1) and COX 2, showing the concentration of non-steroidal anti-inflammatory drugs needed to inhibit the activity of COX 1 and COX 2 by 50% in assays of whole blood. Diagonal line shows equivalence (adapted from FitzGerald and Patrono10)
See this image and copyright information in PMC

References

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    1. Tanaka Y, Ward SL, Smith WL. Immunohistochemical and kinetic evidence for two different prostaglandin H-prostaglandin E isomerases in sheep vesicular gland microsomes. J Biol Chem 1987;262: 1374-81. - PubMed
    1. FitzGerald GA. Cardiovascular pharmacology of nonselective nonsteroidal anti-inflammatory drugs and coxibs: clinical considerations. Am J Cardiol 2002;89(suppl): D26-32. - PubMed

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