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Review
. 2006 May;7(5):342-50.
doi: 10.1631/jzus.2006.B0342.

Interactions between mycoplasma lipid-associated membrane proteins and the host cells

Xiao-xing You  1 , Yan-hua Zeng, Yi-mou Wu
Affiliations
Review

Interactions between mycoplasma lipid-associated membrane proteins and the host cells

Xiao-xing You et al. J Zhejiang Univ Sci B. 2006 May.

Abstract

Mycoplamas are a group of wall-less prokaryotes widely distributed in nature, some of which are pathogenic for humans and animals. There are many lipoproteins anchored on the outer face of the plasma membrane, called lipid-associated membrane proteins (LAMPs). LAMPs are highly antigenic and could undergo phase and size variation, and are recognized by the innate immune system through Toll-like receptors (TLR) 2 and 6. LAMPs can modulate the immune system, and could induce immune cells apoptosis or death. In addition, they may associate with malignant transformation of host cells and are also considered to be cofactors in the progression of AIDS.

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References

    1. Akira S, Takeda K, Kaisho T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol. 2001;2(8):675–680. doi: 10.1038/90609. - DOI - PubMed
    1. Baseman JB, Lange M, Criscimagna NL, Giron JA, Thomas CA. Interplay between mycoplasmas and host target cells. Microb Pathog. 1995;19(2):105–116. doi: 10.1006/mpat.1995.0050. - DOI - PubMed
    1. Buwitt-Beckmann U, Heine H, Wiesmuller KH, Jung G, Brock R, Akira S, Ulmer AJ. Toll-like receptor 6-independent signaling by diacylated lipopeptides. Eur J Immunol. 2005;35(1):282–289. doi: 10.1002/eji.200424955. - DOI - PubMed
    1. Chambaud I, Wroblewski H, Blanchard A. Interactions between mycoplasma lipoproteins and the host immune system. Trends Microbiol. 1999;7(12):493–499. doi: 10.1016/S0966-842X(99)01641-8. - DOI - PubMed
    1. Davis KL, Wise KS. Site-specific proteolysis of the MALP-404 lipoprotein determines the release of a soluble selective lipoprotein-associated motif-containing fragment and alteration of the surface phenotype of Mycoplasma fermentans . Infect Immun. 2002;70(3):1129–1135. doi: 10.1128/IAI.70.3.1129-1135.2002. - DOI - PMC - PubMed

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