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Comparative Study
. 2006 Jun;55(2):142-5.
doi: 10.1016/j.neures.2006.02.011. Epub 2006 Apr 17.

Inhibitory effect of total flavone of Abelmoschus manihot L. Medic on NMDA receptor-mediated current in cultured rat hippocampal neurons

Xin-Ping Cheng  1 , Song Qin, Liu-Yi Dong, Jiang-Ning Zhou
Affiliations
Comparative Study

Inhibitory effect of total flavone of Abelmoschus manihot L. Medic on NMDA receptor-mediated current in cultured rat hippocampal neurons

Xin-Ping Cheng et al. Neurosci Res. 2006 Jun.

Abstract

The modulatory effect of Total Flavone of Abelmoschus manihot L. Medic (TFA) on NMDA-activated current (I(NMDA)) was investigated in cultured rat hippocampal neurons using the whole-cell patch-clamp technique. TFA rapidly and reversibly inhibited the I(NMDA) in a concentration-dependent manner. Furthermore, TFA non-competitively inhibited the I(NMDA) by enhancement of the NMDA receptor desensitization. In addition, intracellular application of TFA did not alter the TFA inhibition of I(NMDA). These results suggest that the inhibition of the NMDA receptor response by TFA could be one of the mechanisms for TFA-mediated neuroprotective actions.

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