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Review
. 2006 Jul 15;71(2):216-25.
doi: 10.1016/j.cardiores.2006.02.033. Epub 2006 Mar 7.

Reactive oxygen species signaling in vascular smooth muscle cells

Roza E Clempus  1 , Kathy K Griendling
Affiliations
Review

Reactive oxygen species signaling in vascular smooth muscle cells

Roza E Clempus et al. Cardiovasc Res. .

Abstract

Reactive oxygen species (ROS) have been shown to function as important signaling molecules in the cardiovascular system. Vascular smooth muscle cells (VSMCs) contain several sources of ROS, among which the NADPH oxidases are predominant. In VSMCs, ROS mediate many pathophysiological processes, such as growth, migration, apoptosis and secretion of inflammatory cytokines, as well as physiological processes, such as differentiation, by direct and indirect effects at multiple signaling levels. Therefore, it becomes critical to understand the different roles ROS play in the physiology and pathophysiology of VSMCs.

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Figures

Fig. 1
Fig. 1
Pathways of NADPH oxidase activation in response to Ang II in VSMCs. See text for details. Final proof for proteins with dotted line has yet to be obtained.
Fig. 2
Fig. 2
ROS signaling related to growth of VSMCs. See text for details.
See this image and copyright information in PMC

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