Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2006 Jul 15;71(2):216-25.
doi: 10.1016/j.cardiores.2006.02.033. Epub 2006 Mar 7.

Reactive oxygen species signaling in vascular smooth muscle cells

Roza E Clempus  1 , Kathy K Griendling
Affiliations
Review

Reactive oxygen species signaling in vascular smooth muscle cells

Roza E Clempus et al. Cardiovasc Res. .

Abstract

Reactive oxygen species (ROS) have been shown to function as important signaling molecules in the cardiovascular system. Vascular smooth muscle cells (VSMCs) contain several sources of ROS, among which the NADPH oxidases are predominant. In VSMCs, ROS mediate many pathophysiological processes, such as growth, migration, apoptosis and secretion of inflammatory cytokines, as well as physiological processes, such as differentiation, by direct and indirect effects at multiple signaling levels. Therefore, it becomes critical to understand the different roles ROS play in the physiology and pathophysiology of VSMCs.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Pathways of NADPH oxidase activation in response to Ang II in VSMCs. See text for details. Final proof for proteins with dotted line has yet to be obtained.
Fig. 2
Fig. 2
ROS signaling related to growth of VSMCs. See text for details.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Finkel T. Signal transduction by reactive oxygen species in non-phagocytic cells. J Leukoc Biol. 1999;65:337–40. - PubMed
    1. Tsutsui M. Neuronal nitric oxide synthase as a novel anti-atherogenic factor. J Atheroscler Thromb. 2004;11:41–8. - PubMed
    1. Griendling KK, Minieri CA, Ollerenshaw JD, Alexander RW. Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells. Circ Res. 1994;74:1141–8. - PubMed
    1. Marumo T, Schini-Kerth VB, Fisslthaler B, Busse R. Platelet-derived growth factor stimulated superoxide anion production modulates activation of transcription factor NF-kappaB and expression of monocyte chemoattractant protein-1 in human aortic smooth muscle cells. Circ. 1997;96:2361–7. - PubMed
    1. Ramachandran A, Levonen AL, Brookes PS, Ceaser E, Shiva S, Barone MC, et al. Mitochondria, nitric oxide, and cardiovascular dysfunction. Free Radic Biol Med. 2002;33:1465–74. - PubMed

Publication types

MeSH terms