Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2005 Dec;2(4):340-5.
doi: 10.1111/j.1742-4801.2005.00103.x.

Segmental ulcerative vasculitis: a cutaneous manifestation of Takayasu's arteritis

Assen L Dourmishev  1 , Dimitrina K Serafimova, Snejina G Vassileva, Lyubomir A Dourmishev, Robert A Schwartz
Affiliations
Case Reports

Segmental ulcerative vasculitis: a cutaneous manifestation of Takayasu's arteritis

Assen L Dourmishev et al. Int Wound J. 2005 Dec.

Abstract

A 16-year-old girl with pyoderma gangrenosum (PG)-like skin lesions on the extremities, trunk and face developed Takayasu's arteritis (TA; pulseless disease). After 3 years under maintenance cyclosporin A therapy, the patient developed an ischaemic cerebral accident. Severe obstruction of both subclavian and left carotid arteries was found by Doppler sonography, angiography and computerised axial tomography. Evolution of this disease showed some characteristic findings: (a) PG-like lesions as the first cutaneous manifestation of pulseless disease; (b) methotrexate and cyclosporin A giving good results for the cutaneous lesions, but apparently not exerting an influence on the evolution of TA and the fatal outcome. This morphologic pattern may reflect underlying TA or Wegener's arteritis, and should be termed segmental ulcerative vasculitis.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Numerous pustules and large superficial ulcers with crusts and inflamed borders on the right hand and cubital joint (possible pathergy phenomenon after venous injections).
Figure 2
Figure 2
Ulcer on the right side of the soft palate (possible pathergy phenomenon after incision).
Figure 3
Figure 3
Multiple symmetrical large superficial ulcers with crusts and inflamed borders on both legs and in dermatomal distribution on abdominal skin.
Figure 4
Figure 4
Epidermal subcorneal pustule with peripheral spongiosis and moderate perivascular infiltrate of lymphocytes and plasma cells in dermis. Haematoxylin – eosin, original magnificent ×100.
Figure 5
Figure 5
Pyoderma‐like lesions on the face, neck and upper trunk.
Figure 6
Figure 6
Cribriform scars and anetoderma at the under arms and flexural contractures in axillae and cubital joints.
Figure 7
Figure 7
Severe obstruction of both subclavian and left carotid arteries and formation of small vessels of aortic arch syndrome documented by angiography.
See this image and copyright information in PMC

References

    1. Perry HO, Winkelman RK, Miller SA et al. Malignant pyoderma. Arch Dermatol 1968; 98: 561–74. - PubMed
    1. Powell F, Winkelmann RK. Malignant pyoderma. Br J Dermatol 1983;109: 597–603. - PubMed
    1. Salassa JR, Winkelmann RK, McDonald TJ. Malignant pyoderma. Otolaryngol Head Neck Surg 1982;89: 917–22. - PubMed
    1. Lee CT, Thirumoorthy T. A case of malignant pyoderma with neurological manifestations. Ann Acad Med Singapore 1988;17: 554–56. - PubMed
    1. Gibson LE, Daoud MS, Muller SA, Perry HO. Malignant pyodermas revisited. Mayo Clin Proc 1997;72: 734–36. - PubMed

Publication types