doi: 10.1021/ja0609708.
Total synthesis of (-)-dictyostatin
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- PMID: 16620095
- DOI: 10.1021/ja0609708
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Total synthesis of (-)-dictyostatin
J Am Chem Soc.
.
Abstract
A convergent total synthesis of dictyostatin is described. Key features of the synthesis include the use of titanium-mediated cyclizations of (silyloxy)enynes for the synthesis of stereotriads, a subunit coupling by metathesis, and macrocyclization by intramolecular Horner-Wadsworth-Emmons olefination.
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