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. 2006 Apr 26;128(16):5340-1.
doi: 10.1021/ja0609708.

Total synthesis of (-)-dictyostatin

Gregory W O'Neil  1 , Andrew J Phillips
Affiliations

Total synthesis of (-)-dictyostatin

Gregory W O'Neil et al. J Am Chem Soc. .

Abstract

A convergent total synthesis of dictyostatin is described. Key features of the synthesis include the use of titanium-mediated cyclizations of (silyloxy)enynes for the synthesis of stereotriads, a subunit coupling by metathesis, and macrocyclization by intramolecular Horner-Wadsworth-Emmons olefination.

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