Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1991 Oct;35(10):2151-4.
doi: 10.1128/AAC.35.10.2151.

Ciprofloxacin resistance in coagulase-positive and -negative staphylococci: role of mutations at serine 84 in the DNA gyrase A protein of Staphylococcus aureus and Staphylococcus epidermidis

S Sreedharan  1 , L R Peterson, L M Fisher
Affiliations

Ciprofloxacin resistance in coagulase-positive and -negative staphylococci: role of mutations at serine 84 in the DNA gyrase A protein of Staphylococcus aureus and Staphylococcus epidermidis

S Sreedharan et al. Antimicrob Agents Chemother. 1991 Oct.

Abstract

gyrA mutations in quinolone-resistant pathogenic isolates of Staphylococcus spp. have been detected by the direct HinfI digestion of polymerase chain reaction products. Homology among gyrA genes allowed rapid examination of both coagulase-positive and -negative isolates. DNA sequence analysis revealed that ciprofloxacin resistance in Staphylococcus epidermidis is associated with a novel Ser-84----Phe mutation in the DNA gyrase A protein, analogous to Ser-84----Leu changes observed in Staphylococcus aureus.

PubMed Disclaimer

References

    1. J Bacteriol. 1990 Dec;172(12):7260-2 - PubMed
    1. N Engl J Med. 1991 Feb 7;324(6):384-94 - PubMed
    1. Antimicrob Agents Chemother. 1990 Sep;34(9):1862-3 - PubMed
    1. J Bacteriol. 1985 Aug;163(2):796-8 - PubMed
    1. Nucleic Acids Res. 1985 Apr 11;13(7):2251-65 - PubMed

Publication types

MeSH terms

LinkOut - more resources