Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1975 Jul;16(1):70-4.
doi: 10.1128/JVI.16.1.70-74.1975.

Fate of polyoma form IDNA during replication

A Roman, R Dulbecco

Fate of polyoma form IDNA during replication

A Roman et al. J Virol. 1975 Jul.

Abstract

The fate of polyoma form IDNA generated during replication was investigated in resting BALB-3T3 cells. The experiments showed that there was extensive re-entry of such molecules into replication. This process took place over a period of several hours and appeared to be random. Progeny form I molecules must, therefore, spend some time in a nonreplicating pool before reinitiating replication. We propose that two factors affect the fate of progeny form IDNA. (i) The rate of reinitiation of progeny molecules is determined by the capacity of the initiation machinery. (ii) The extent of re-entry is determined by the availability of maturation proteins which divert form I from replication.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J Biol Chem. 1961 Sep;236:2514-9 - PubMed
    1. Virology. 1962 Jan;16:41-51 - PubMed
    1. Virology. 1963 Feb;19:158-68 - PubMed
    1. Virology. 1974 Jan;57(1):147-60 - PubMed
    1. Proc Natl Acad Sci U S A. 1965 Jun;53(6):1468-75 - PubMed

Publication types

LinkOut - more resources