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Review
. 2006 Sep;71(2-3):122-6.
doi: 10.1016/j.antiviral.2006.03.002. Epub 2006 Mar 30.

Ribonucleotide reductase inhibitors as anti-herpes agents

Stanislaw F Wnuk  1 , Morris J Robins
Affiliations
Review

Ribonucleotide reductase inhibitors as anti-herpes agents

Stanislaw F Wnuk et al. Antiviral Res. 2006 Sep.

Abstract

Ribonucleotide reductases (RNRs) supply the 2'-deoxyribonucleotide building blocks for DNA synthesis in mammalian cells and for herpes viruses. The viral-encoded RNRs have unique protein sequences that differ from mammalian enzyme primary structures. Selective inhibition of a viral RNR might provide an approach to new anti-herpes agents with minimal effects on the mammalian host RNRs. This review summarizes efforts to develop anti-herpes agents that selectively target viral-encoded RNRs.

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