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. 2006 May;13(5):462-4.
doi: 10.1038/nsmb1081. Epub 2006 Apr 23.

EJC-independent degradation of nonsense immunoglobulin-mu mRNA depends on 3' UTR length

Marc Bühler  1 , Silvia Steiner, Fabio Mohn, Alexandra Paillusson, Oliver Mühlemann
Affiliations

EJC-independent degradation of nonsense immunoglobulin-mu mRNA depends on 3' UTR length

Marc Bühler et al. Nat Struct Mol Biol. 2006 May.

Abstract

Inconsistent with prevailing models for nonsense-mediated mRNA decay (NMD) in mammals, the mRNA levels of immunoglobulin-mu (Ig-mu) genes with premature termination codons (PTCs) in the penultimate exon are still reduced by NMD when the intron furthest downstream is deleted. As in yeast, this exon junction complex-independent NMD of Ig-mu mRNAs depends on the distance between the termination codon and the poly(A) tail and suggests an evolutionarily conserved mode of PTC recognition.

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