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Randomized Controlled Trial
. 2006 Mar;23(3):137-40.
doi: 10.1007/s10815-005-9008-y. Epub 2006 Apr 19.

A prospective randomized trial of conventional in vitro fertilization versus intracytoplasmic sperm injection in unexplained infertility

Shu C Foong  1 , Judy A Fleetham, Joseph A O'Keane, Selma G Scott, Suzanne C Tough, Calvin A Greene
Affiliations
Randomized Controlled Trial

A prospective randomized trial of conventional in vitro fertilization versus intracytoplasmic sperm injection in unexplained infertility

Shu C Foong et al. J Assist Reprod Genet. 2006 Mar.

Abstract

Purpose: To compare outcomes in patients with unexplained infertility undergoing conventional in vitro fertilization (IVF) versus intracytoplasmic sperm injection (ICSI).

Methods: Sixty women with unexplained infertility in a Canadian tertiary-level clinic were randomized to IVF or ICSI. Subjects underwent downregulation with gonadotropin-releasing hormone agonist prior to initiation of recombinant human follicle-stimulating hormone. The primary outcome measure was fertilization rate. Secondary outcomes included implantation rate, embryo quality, clinical pregnancy rate, and live birth rate.

Results: There was no statistically significant difference in fertilization rate (77.2% IVF vs. 82.4% ICSI), implantation rate (38.2% IVF vs. 44.4% ICSI), clinical pregnancy rate (50% in each group), or live birth rate (46.7% IVF vs. 50% ICSI). There were two cases of failed fertilization in the IVF group. There was no significant difference in embryo quality between groups.

Conclusions: There were no differences in clinical outcomes associated with IVF versus ICSI in the treatment of unexplained infertility.

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References

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