Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2006 Sep;36(5):640-50.
doi: 10.1007/s10519-006-9069-4.

Association of GABRA2 with drug dependence in the collaborative study of the genetics of alcoholism sample

Arpana Agrawal  1 , Howard J Edenberg, Tatiana Foroud, Laura J Bierut, Gerald Dunne, Anthony L Hinrichs, John I Nurnberger, Raymond Crowe, Samuel Kuperman, Marc A Schuckit, Henri Begleiter, Bernice Porjesz, Danielle M Dick
Affiliations

Association of GABRA2 with drug dependence in the collaborative study of the genetics of alcoholism sample

Arpana Agrawal et al. Behav Genet. 2006 Sep.

Abstract

Results from twin studies suggest that overlapping genetic factors influence alcohol dependence and illicit drug dependence. Using data from the Collaborative Study on the Genetics of Alcoholism (COGA), we examined the association between 69 SNPs in the GABAA receptor gene cluster on chromosome 4 and marijuana and illicit drug dependence, individually, and as co-occurring phenotypes with alcohol dependence. Results suggested association between marijuana dependence and illicit drug dependence with SNPs in the GABRA2 gene. Interestingly, the evidence for association previously observed with alcohol dependence came only from individuals with comorbid illicit drug dependence. There was no association with other genes in the GABAA cluster on chromosome 4 with illicit drug dependence.

PubMed Disclaimer

Publication types