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. 1991 Dec 25;19(24):6929-34.
doi: 10.1093/nar/19.24.6929.

Phylogenetic and physical analysis of the 5' leader RNA sequences of avian retroviruses

P B Hackett  1 , M W Dalton, D P Johnson, R B Petersen
Affiliations
Free PMC article

Phylogenetic and physical analysis of the 5' leader RNA sequences of avian retroviruses

P B Hackett et al. Nucleic Acids Res. .
Free PMC article

Abstract

A study of the secondary structures of the 5'-leader RNA sequences of avian leukosis/sarcoma viruses was conducted using phylogenetic sequence alignment, theoretical structures calculated from base-pairing interactions involving the calculated minimal delta G values, and RNaseT1 sensitivity. The results suggest that all of the avian retroviral RNA leaders may be able to adopt similar conformations. Open reading frames in the leader RNAs may be positioned to facilitate viral activities such as translation and packaging of the genomic RNA into virus particles.

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