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Review
. 2006 Aug;1758(8):1117-25.
doi: 10.1016/j.bbamem.2006.03.004. Epub 2006 Mar 31.

Regulation of aquaporin-2 trafficking and its binding protein complex

Yumi Noda  1 , Sei Sasaki
Affiliations
Free article
Review

Regulation of aquaporin-2 trafficking and its binding protein complex

Yumi Noda et al. Biochim Biophys Acta. 2006 Aug.
Free article

Abstract

Trafficking of water channel aquaporin-2 (AQP2) to the apical membrane is critical to water reabsorption in renal collecting ducts and its regulation maintains body water homeostasis. However, exact molecular mechanisms which recruit AQP2 are unknown. Recent studies highlighted a key role for spatial and temporal regulation of actin dynamics in AQP2 trafficking. We have recently identified AQP2-binding proteins which directly regulate this trafficking: SPA-1, a GTPase-activating protein (GAP) for Rap1, and cytoskeletal protein actin. In addition, a multiprotein "force generator" complex which directly binds to AQP2 has been discovered. This review summarizes recent advances related to the mechanism for AQP2 trafficking.

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