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. 2006 Jul;173(3):1829-32.
doi: 10.1534/genetics.105.052977. Epub 2006 Apr 19.

The hitchhiking effect of an autosomal meiotic drive gene

Luis-Miguel Chevin  1 , Frédéric Hospital
Affiliations

The hitchhiking effect of an autosomal meiotic drive gene

Luis-Miguel Chevin et al. Genetics. 2006 Jul.

Abstract

Transmission-ratio distortion is a departure from a 1:1 segregation of alleles in the gametes of a heterozygous individual. The so-called driving allele is strongly selected regardless of its effect on the fitness of the carrying individual. It may then have an important impact on neutral polymorphism due to the genetic hitchhiking effect. We study this hitchhiking effect in the case of true meiotic drive in autosomes and show that it is more dependent on the recombination rate than in the classical case of a gene positively selected at the organism level.

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