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. 2006 Aug 8;67(3):485-7.
doi: 10.1212/01.wnl.0000218215.43328.88. Epub 2006 Apr 19.

Identification of an oculomotor biomarker of preclinical Huntington disease

C V P Golding  1 , C Danchaivijitr, T L Hodgson, S J Tabrizi, C Kennard
Affiliations

Identification of an oculomotor biomarker of preclinical Huntington disease

C V P Golding et al. Neurology. .

Abstract

The authors examined oculomotor function to identify a biomarker of disease progression in genetically confirmed preclinical and early clinical Huntington disease (HD). Initiation deficits of voluntary-guided, but not reflexive, saccades were characteristic of preclinical HD. Saccadic slowing and delayed reflexive saccades were demonstrated in clinical but not preclinical HD. Saccadic measures provide biomarkers of disease progression in both preclinical and early clinical stages of HD.

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