Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2006 Sep;71(2-3):108-16.
doi: 10.1016/j.antiviral.2006.03.006. Epub 2006 Apr 4.

Anti-inflammatory properties of Type I interferons

Alfons Billiau  1
Affiliations
Review

Anti-inflammatory properties of Type I interferons

Alfons Billiau. Antiviral Res. 2006 Sep.

Abstract

The notion that Type I interferons (interferon-alpha and -beta) possess anti-inflammatory potential is supported by data from clinical application in multiple sclerosis, by studies on cultured immune-competent cells and by investigation of experimental diseases in whole animals. These observations deserve the attention of virologists for their potential role in the pathogenesis and clinical management of virus infections.

PubMed Disclaimer

References

    1. Abreu S.L. Suppression of experimental allergic encephalomyelitis by interferon. Immunol. Commun. 1982;11:1–7. - PubMed
    1. Abreu S.L., Tondreau J., Levine S., Sowinski R. Inhibition of passive localized experimental allergic encephalomyelitis by interferon. Int. Arch. Allergy Appl. Immunol. 1983;72:30–33. - PubMed
    1. Abu-khabar K.S., Armstrong J.A., Ho M. Type I interferons (IFN-α and -β) suppress cytotoxin (tumor necrosis factor-α and lymphotoxin) production by mitogen-stimulated human peripheral blood mononuclear cells. J. Leukocyte Biol. 1992;52:165–172. - PubMed
    1. Avolio C., Filippi M., Tortorella C., Rocca M.A., Ruggieri M., Agosta F., Tomassini V., Pozzilli C., Stecchi S., Giaquinto P., Livrea P., Trojano M. Serum MMP-9/TIMP-1 and MMP-2/TIMP-2 ratios in multiple sclerosis: relationships with different magnetic resonance imaging measures of disease activity during IFN-beta-1a treatment. Mult. Scler. 2005;11:441–446. - PubMed
    1. Azzaroli F., Accogli E., Nigro G., Trere D., Giovanelli S., Miracolo A., Lodato F., Montagnani M., Tame M., Colecchia A., Mwangemi C., Festi D., Roda E., Derenzini M., Mazzella G. Interferon plus ribavirin and interferon alone in preventing hepatocellular carcinoma: a prospective study on patients with HCV related cirrhosis. World J. Gastroenterol. 2004;10:3099–3102. - PMC - PubMed