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. 2006 May;61(5):629-32.
doi: 10.1111/j.1398-9995.2006.01076.x.

Low prevalence of the intrinsic form of atopic dermatitis among adult patients

R Fölster-Holst  1 , M Pape, Y L Buss, E Christophers, M Weichenthal
Affiliations

Low prevalence of the intrinsic form of atopic dermatitis among adult patients

R Fölster-Holst et al. Allergy. 2006 May.

Abstract

Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease commonly associated with respiratory allergies such as rhinitis and asthma, and a high serum level of IgE. In contrast to the 'classic' IgE-mediated allergic (extrinsic) form of AD, approximately 20% of the patients are reported to show normal IgE levels, lack of sensitizations towards environmental allergens, and absence of associated respiratory allergies. Accordingly, these patients are assigned to a nonallergic (intrinsic) form of the disease.

Objectives: In order to define these two forms of AD more closely, 259 adult patients with AD were investigated.

Results: After a thorough diagnostic workup there were 18 patients (6.9%), who fulfilled the criteria of intrinsic AD. After follow-up, four additional patients had developed respiratory allergies or IgE-mediated sensitizations resulting in an overall proportion for intrinsic AD of 5.4%.

Conclusions: Based on these figures the nature and relevance of the intrinsic form of AD deserves further evaluation.

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