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. 2006 Jun 9;344(3):786-91.
doi: 10.1016/j.bbrc.2006.03.195. Epub 2006 Apr 17.

Neurogenesin-1 differentially inhibits the osteoblastic differentiation by bone morphogenetic proteins in C2C12 cells

Abhishek Chandra  1 , Tatsuo Itakura, Zhi Yang, Tomoki Tamakoshi, XiaoDong Xue, Bo Wang, Takatoshi Ueki, Kohji Sato, Tadayoshi Uezato, Naoyuki Miura
Affiliations

Neurogenesin-1 differentially inhibits the osteoblastic differentiation by bone morphogenetic proteins in C2C12 cells

Abhishek Chandra et al. Biochem Biophys Res Commun. .

Abstract

Bone morphogenetic protein (BMP) antagonists regulate the pleiotropic actions of BMPs by binding to BMPs. We previously isolated the Neurogenesin-1 (Ng1) gene and found that Ng1 protein induces neuronal differentiation in the brain. In this study, we found that Ng1 was expressed in the primordial cells of the skeleton and investigated whether Ng1 protein inhibited the BMP action to induce osteoblastic differentiation in C2C12 myoblasts. Interestingly, Ng1 protein inhibited the BMP7-induced alkaline phosphatase activity while it did not inhibit the BMP2-induced activity. All data suggest that Ng1 protein plays an important role in the embryonic bone formation by differentially regulating BMPs.

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