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Case Reports
. 2006 May;13(5):453-5.
doi: 10.1016/j.arcped.2006.02.012. Epub 2006 Apr 21.

[Family observation of Kawasaki disease: 2 cases in sister and brother]

[Article in French]
Affiliations
Case Reports

[Family observation of Kawasaki disease: 2 cases in sister and brother]

[Article in French]
M Caquard et al. Arch Pediatr. 2006 May.

Abstract

This article presents the clinical observation of 2 cases of children suffering from Kawasaki disease in the same family at a 7-year interval. This observation suggests a genetic predisposition to the disease. Epidemiological surveys conducted in Japan for some years point to a genetic factor but without proof. Childhood systemic febrile vasculitis is hard to recognise, so its diagnosis is often made lately, while there is an effective therapy, which prevents from serious cardiovascular complications. Identification of its precise cause, a necessary step before any diagnostic laboratory test, will be a major breakthrough.

Nous présentons 2 cas de maladie de Kawasaki survenus dans une même fratrie à 7 ans d'intervalle. Ces observations soulèvent à nouveau l'hypothèse d'une prédisposition génétique de cette affection. Depuis plusieurs années, des enquêtes épidémiologiques menées au Japon évoquent l'hypothèse d'un facteur génétique sans en faire la preuve. Cette vascularite fébrile de l'enfant reste de diagnostic difficile, et donc souvent retardé, alors que l'on dispose d'un traitement efficace permettant de prévenir ses complications cardiaques, faisant toute la gravité de la maladie. L'identification de son étiologie précise, étape préalable indispensable à la mise au point d'un éventuel marqueur diagnostique spécifique, constituerait un progrès majeur.

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