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Review
. 2006 Apr 21;125(2):233-6.
doi: 10.1016/j.cell.2006.04.004.

Searching chromatin for stem cell identity

Michael Buszczak  1 , Allan C Spradling
Affiliations
Free article
Review

Searching chromatin for stem cell identity

Michael Buszczak et al. Cell. .
Free article

Abstract

Stem cells encapsulate the fundamental problem of metazoan biology in miniature: How do cells establish and maintain their fates? Increasing evidence indicates that stem cell chromatin activates proliferation genes and represses differentiation genes. Understanding how these configurations are stabilized by Polycomb group proteins will advance our understanding of embryonic development, tissue homeostasis, regeneration, aging, and oncogenesis.

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Comment on

  • Control of developmental regulators by Polycomb in human embryonic stem cells.
    Lee TI, Jenner RG, Boyer LA, Guenther MG, Levine SS, Kumar RM, Chevalier B, Johnstone SE, Cole MF, Isono K, Koseki H, Fuchikami T, Abe K, Murray HL, Zucker JP, Yuan B, Bell GW, Herbolsheimer E, Hannett NM, Sun K, Odom DT, Otte AP, Volkert TL, Bartel DP, Melton DA, Gifford DK, Jaenisch R, Young RA. Lee TI, et al. Cell. 2006 Apr 21;125(2):301-13. doi: 10.1016/j.cell.2006.02.043. Cell. 2006. PMID: 16630818 Free PMC article.
  • A bivalent chromatin structure marks key developmental genes in embryonic stem cells.
    Bernstein BE, Mikkelsen TS, Xie X, Kamal M, Huebert DJ, Cuff J, Fry B, Meissner A, Wernig M, Plath K, Jaenisch R, Wagschal A, Feil R, Schreiber SL, Lander ES. Bernstein BE, et al. Cell. 2006 Apr 21;125(2):315-26. doi: 10.1016/j.cell.2006.02.041. Cell. 2006. PMID: 16630819

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