XPB: An essential helicase involved in both transcription and repair of DNA
- PMID: 16630882
- DOI: 10.1016/j.molcel.2006.04.001
XPB: An essential helicase involved in both transcription and repair of DNA
Abstract
Helicases are molecular motors known to unwind double-stranded DNA. In a recent issue of Molecular Cell, Fan et al. (2006) revealed the core structure of XPB helicase, a component of transcription factor IIH, and proposed a mechanism for its dual role in transcription and nucleotide excision repair.
Comment on
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Conserved XPB core structure and motifs for DNA unwinding: implications for pathway selection of transcription or excision repair.Mol Cell. 2006 Apr 7;22(1):27-37. doi: 10.1016/j.molcel.2006.02.017. Mol Cell. 2006. PMID: 16600867
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