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. 2006 Sep 15;22(18):2317-8.
doi: 10.1093/bioinformatics/btl153. Epub 2006 Apr 21.

GeneRecon--a coalescent based tool for fine-scale association mapping

Thomas Mailund  1 , Mikkel H Schierup, Christian N S Pedersen, Jesper N Madsen, Jotun Hein, Leif Schauser
Affiliations

GeneRecon--a coalescent based tool for fine-scale association mapping

Thomas Mailund et al. Bioinformatics. .

Abstract

GeneRecon is a tool for fine-scale association mapping using a coalescence model. GeneRecon takes as input case-control data from phased or unphased SNP and microsatellite genotypes. The posterior distribution of disease locus position is obtained by Metropolis-Hastings sampling in the state space of genealogies. Input format, search strategy and the sampled statistics can be configured through the Guile Scheme programming language embedded in GeneRecon, making GeneRecon highly configurable.

Availability: The source code for GeneRecon, written in C++ and Scheme, is available under the GNU General Public License (GPL) at http://www.birc.au.dk/~mailund/GeneRecon

Contact: mailund@birc.au.dk.

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