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Review
. 2006 May;7(5):323-34.
doi: 10.1038/nrm1908.

Regulation of DNA repair by ubiquitylation

Tony T Huang  1 , Alan D D'Andrea
Affiliations
Review

Regulation of DNA repair by ubiquitylation

Tony T Huang et al. Nat Rev Mol Cell Biol. 2006 May.

Abstract

The process of ubiquitylation is best known for its role in targeting proteins for degradation by the proteasome. However, recent studies of DNA-repair and DNA-damage-response pathways have significantly broadened the scope of the role of ubiquitylation to include non-proteolytic functions of ubiquitin. These pathways involve the monoubiquitylation of key DNA-repair proteins that have regulatory functions in homologous recombination and translesion DNA synthesis, and involve the polyubiquitylation of nucleotide-excision-repair proteins.

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