Review
doi: 10.1016/0955-0674(91)90035-w.
Molecular recognition and targeting of lysosomal proteins
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- PMID: 1663372
- DOI: 10.1016/0955-0674(91)90035-w
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Review
Molecular recognition and targeting of lysosomal proteins
Curr Opin Cell Biol.
1991 Aug.
Abstract
Recent studies have established that in mammalian cells insulin-like growth factor-II can couple the large mannose-6-phosphate receptor to a GTP-binding protein and that the insulin-like growth factor-II-induced activation of the GTP-binding protein is inhibited by mannose-6-phosphate and lysosomal enzymes. In mouse, the gene for the large mannose-6-phosphate receptor is maternally imprinted.
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