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Case Reports
. 2006 Apr;67(4):318-20.
doi: 10.1111/j.1399-0039.2006.00565.x.

Identification of a novel 120 bp allele at the TNFd microsatellite locus

I J Wastowski  1 , N T A Peres, R T Simões, E C Castelli, A L Simões, N M Martinez-Rossi, E A Donadi
Affiliations
Case Reports

Identification of a novel 120 bp allele at the TNFd microsatellite locus

I J Wastowski et al. Tissue Antigens. 2006 Apr.

Abstract

Tumor necrosis factor-alpha (TNF-alpha) is a pro-inflammatory cytokine mainly secreted by macrophages and T-cells that play a key role in the pathogenesis of many infectious and inflammatory diseases. The TNF gene cluster is located within the class-III region of the highly polymorphic major histocompatibility complex on human chromosome 6p21. A cluster of six multiallelic microsatellites has been identified in the TNF region, named TNF a-e. TNFb, TNFc, TNFd, and TNFe are (GA)n repeats, whereas TNFa and TNFf are (GT)n and (CA)n repeats, respectively. The TNFd microsatellite locus maps 8-10 kb centromeric to the TNF-alpha gene, downstream to the TNF-beta gene.

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