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. 2006 Apr 25;66(8):1255-7.
doi: 10.1212/01.wnl.0000208433.34723.65.

Monocyte chemoattractant protein-1 correlates with subcortical brain injury in HIV infection

A B Ragin  1 , Y Wu, P Storey, B A Cohen, R R Edelman, L G Epstein
Affiliations

Monocyte chemoattractant protein-1 correlates with subcortical brain injury in HIV infection

A B Ragin et al. Neurology. .

Abstract

Various biomarkers have been suggested as associative or predictive of HIV-associated neurocognitive impairment. Plasma levels of monocyte chemoattractant protein 1 (MCP-1), tumor necrosis factor alpha (TNF-alpha), and hematocrit were evaluated for relationships with diffusion tensor imaging measurements of centrum semiovale, caudate, and putamen. MCP-1 levels correlated with tissue status (mean diffusivity) in all examined regions. Plasma markers were also significantly correlated with anisotropy measurements in centrum semiovale (TNF-alpha) and putamen (hematocrit).

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Conflict of interest statement

Disclosure: The authors report no conflicts of interest.

Figures

Figure 1
Figure 1
Regions of interest (ROIs) for putamen and caudate nuclei as shown on an axial slice through interventricular foramen (top). ROIs for centrum semiovale were placed on an axial slice above the bilateral ventricles (bottom). ROI (43 mm2) measurements were acquired in each hemisphere and then averaged.
Figure 2
Figure 2
Relationship between monocyte chemoattractant protein 1 (MCP-1) and mean diffusivity (MD) for each region.
Figure 3
Figure 3
Relationship between tumor necrosis factor α (TNF-α) and anisotropy in deep white matter.
See this image and copyright information in PMC

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