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Comparative Study
. 2006 Aug;21(8):1277-9.
doi: 10.1002/mds.20896.

End of day dyskinesia in advanced Parkinson's disease can be eliminated by bilateral subthalamic nucleus or globus pallidus deep brain stimulation

Diana Apetauerova  1 , R Kevin Ryan, Susie I Ro, Jeffrey Arle, Jay Shils, Efstathios Papavassiliou, Daniel Tarsy
Affiliations
Comparative Study

End of day dyskinesia in advanced Parkinson's disease can be eliminated by bilateral subthalamic nucleus or globus pallidus deep brain stimulation

Diana Apetauerova et al. Mov Disord. 2006 Aug.

Abstract

We report the therapeutic effects of deep brain stimulation (DBS) in 2 patients with Parkinson's disease (PD) with severe end of dose dyskinesia that was resistant to medical therapy. In both patients, severe, end of day ballistic dyskinesias occurred when the last levodopa dose of the day was wearing off. Globus pallidus (GPi) DBS in 1 case and subthalamic (STN) DBS in the second case produced full resolution of end of day dyskinesia.

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