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. 2006 Mar-Apr;32(2):161-8.

[Peptide fragment 66-77 of monocyte chemoattractant protein 1 and its retro-enantio analogue inhibits the migration of cells in vitro and in vivo]

[Article in Russian]
M V Sidorova, A S Molokoedov, A A Az'muko, T I Aref'eva, M G Melekhov, N B Kukhtina, T L Krasnikova, Zh D Bespalova, V N Bushuev
  • PMID: 16637287

[Peptide fragment 66-77 of monocyte chemoattractant protein 1 and its retro-enantio analogue inhibits the migration of cells in vitro and in vivo]

[Article in Russian]
M V Sidorova et al. Bioorg Khim. 2006 Mar-Apr.

Abstract

The retro-enantio analogue of peptide 66-77 of the chemokine MCP-1 and two hexapeptide fragments 66-71 and 72-77 of the C-terminal sequence of this protein were synthesized using the Fmoc strategy of solid phase peptide synthesis. The effect of the synthetic peptides upon the MCP-1-stimulated migration of THP-1 mononuclear cells was studied in vitro. The activity of the retro-enantio analogue was found to be comparable with that of the initial peptide 66-77: both peptides inhibit the migration of monocytes and granulocytes into inflammation zones of experimental animals.

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