A new initiative for the development of new diagnostic tests for human African trypanosomiasis
- PMID: 16638141
- PMCID: PMC1464096
- DOI: 10.1186/1475-9292-5-1
A new initiative for the development of new diagnostic tests for human African trypanosomiasis
Abstract
Human African trypanosomiasis is a threat to millions of people living in sub-Saharan countries and is fatal unless treated. At present, the serological and parasitological tests used in the field for diagnosis of sleeping sickness have low specificity and sensitivity. There is clearly an urgent need for accurate tools for both diagnosis and staging of the disease. The Foundation for Innovative New Diagnostics and the World Health Organization have announced that they will collaborate to develop and evaluate new diagnostic tests for human African trypanosomiasis.
Similar articles
-
Update on human African trypanosomiasis (sleeping sickness).J Neurol. 2019 Sep;266(9):2334-2337. doi: 10.1007/s00415-019-09425-7. Epub 2019 Jun 17. J Neurol. 2019. PMID: 31209574 Review.
-
A novel and accurate diagnostic test for human African trypanosomiasis.Lancet. 2004 Apr 24;363(9418):1358-63. doi: 10.1016/S0140-6736(04)16046-7. Lancet. 2004. PMID: 15110493
-
Priorities for the elimination of sleeping sickness.Adv Parasitol. 2012;79:299-337. doi: 10.1016/B978-0-12-398457-9.00004-4. Adv Parasitol. 2012. PMID: 22726645 Review.
-
The challenging problem of disease staging in human African trypanosomiasis (sleeping sickness): a new approach to a circular question.Trans R Soc Trop Med Hyg. 2017 May 1;111(5):199-203. doi: 10.1093/trstmh/trx034. Trans R Soc Trop Med Hyg. 2017. PMID: 28957467
-
Prevalence of domestic animal trypanosomiasis in the Fontem sleeping sickness focus, Cameroon.Rev Elev Med Vet Pays Trop. 1990;43(1):69-74. Rev Elev Med Vet Pays Trop. 1990. PMID: 2263747
Cited by
-
The history of African trypanosomiasis.Parasit Vectors. 2008 Feb 12;1(1):3. doi: 10.1186/1756-3305-1-3. Parasit Vectors. 2008. PMID: 18275594 Free PMC article.
-
Hypocretin and human African trypanosomiasis.Sleep. 2008 Mar;31(3):348-54. doi: 10.1093/sleep/31.3.348. Sleep. 2008. PMID: 18363311 Free PMC article.
-
Identification of human African Trypanosomiasis foci using school-going children in post-conflict era in Nwoya District, Northern Uganda: A cross-sectional study.AAS Open Res. 2018 Apr 18;1:8. doi: 10.12688/aasopenres.12851.1. eCollection 2018. AAS Open Res. 2018. PMID: 32382695 Free PMC article.
-
Proteomic selection of immunodiagnostic antigens for human African trypanosomiasis and generation of a prototype lateral flow immunodiagnostic device.PLoS Negl Trop Dis. 2013;7(2):e2087. doi: 10.1371/journal.pntd.0002087. Epub 2013 Feb 28. PLoS Negl Trop Dis. 2013. PMID: 23469310 Free PMC article.
References
-
- Magnus E, Vervoort T, Van Meirvenne N. A card-agglutination test with stained trypanosomes (C.A.T.T.) for the serological diagnosis of T. b. gambiense trypanosomiasis. Ann Soc Belg Med Trop. 1978;58:169–176. - PubMed
-
- Medical Tropical Institute, Antwerp CATT Manual http://www.msf.org/source/refbooks/MSF_Docs/En/Catalog/D/DGT/DDGTTRYT2R-...
-
- Noireau F, Lemesre JL, Nzoukoudi MY, Louembet MT, Gouteaux JP, Frezil JL. Serodiagnosis of sleeping sickness in the Republic of the Congo: comparison of indirect immunofluorescent antibody test and card agglutination test. Trans R Soc Trop Med Hyg. 1988;82:237–240. doi: 10.1016/0035-9203(88)90430-0. - DOI - PubMed
LinkOut - more resources
Full Text Sources