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Review
. 2006 Apr;14(2):413-5.

[Regulatory effects of Bmi-1 gene on self-renewal of hematopoietic stem cells--review]

[Article in Chinese]
Hui Gong  1 , Yi-Cheng Zhang, Wen-Li Liu
Affiliations
  • PMID: 16638228
Review

[Regulatory effects of Bmi-1 gene on self-renewal of hematopoietic stem cells--review]

[Article in Chinese]
Hui Gong et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2006 Apr.

Abstract

Self-renewal of hematopoietic stem cells is vital for the sustained daily production of blood cells. The Bmi-1 gene is a putative oncogene belonging to the Polycomb group family. Recent studies have shown that the Polycomb-group gene Bmi-1 is indispensable for regulation of self-renewal of normal and leukemic stem cells. The research progress on structure and function of Bmi-1 gene, and its role in self-renewal of hematopoietic stem cells was reviewed.

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