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Review
. 2006 Mar;13(3):235-6.
doi: 10.1016/j.chembiol.2006.03.002.

Sometimes intermediates. Do the job!

Rolf Hilgenfeld  1 , Ksenia Pumpor
Affiliations
Review

Sometimes intermediates. Do the job!

Rolf Hilgenfeld et al. Chem Biol. 2006 Mar.

Abstract

The SARS coronavirus main proteinase is a prime target for antiviral therapy. In this issue of Chemistry & Biology, Wu et al. describe potent inhibition of the enzyme by benzotriazole esters, which were originally obtained as intermediates in the synthesis of lopinavir derivatives .

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Figures

Figure 1
Figure 1
Chemical formulas of (A) AG7088, (B-D) AG7088 derivatives, (E) lopinavir, (F) 1-(benzoyloxy)-benzotriazole (R=4-NHCH3, 4-N(CH3)2, or 4-N(C2H5)2).
See this image and copyright information in PMC

Comment on

References

    1. Wu C.-Y., King K.-Y., Kuo C.-J., Fang J.-M., Wu Y.-T., Ho M.-Y., Liao C.-L., Shie J.-J., Liang P.-H., Wong C.-H. Chem. Biol. 2006;13:261–268. this issue. - PMC - PubMed
    1. Anand K., Palm G.J., Mesters J.R., Siddell S.G., Ziebuhr J., Hilgenfeld R. EMBO J. 2002;21:3213–3224. - PMC - PubMed
    1. Barretto N., Jukneliene D., Ratia K., Chen Z., Mesecar A.D., Baker S.C. J. Virol. 2005;79:15189–15198. - PMC - PubMed
    1. Lindner H.A., Fotouhi-Ardakani N., Lytvyn V., Lachance P., Sulea T., Ménard R. J. Virol. 2005;79:15199–15208. - PMC - PubMed
    1. Anand K., Yang H., Bartlam M., Rao Z., Hilgenfeld R. In: Coronaviruses with Special Emphasis on First Insights Concerning SARS. Schmidt A., Wolff M.H., Weber O., editors. Basel; 2005. pp. 173–199.

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