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. 2006 Apr;70(2):121-7.

Challenge with Bovine viral diarrhea virus by exposure to persistently infected calves: protection by vaccination and negative results of antigen testing in nonvaccinated acutely infected calves

Robert W Fulton  1 , Bill J Johnson, Robert E Briggs, Julia F Ridpath, Jeremiah T Saliki, Anthony W Confer, Lurinda J Burge, Douglas L Step, Derek A Walker, Mark E Payton
Affiliations

Challenge with Bovine viral diarrhea virus by exposure to persistently infected calves: protection by vaccination and negative results of antigen testing in nonvaccinated acutely infected calves

Robert W Fulton et al. Can J Vet Res. 2006 Apr.

Abstract
in English, French

Calves persistently infected (PI) with Bovine viral diarrhea virus (BVDV) represent an important source of infection for susceptible cattle. We evaluated vaccine efficacy using calves PI with noncytopathic BVDV2a for the challenge and compared tests to detect BVDV in acutely or transiently infected calves versus PI calves. Vaccination with 2 doses of modified live virus vaccine containing BVDV1a and BVDV2a protected the calves exposed to the PI calves: neither viremia nor nasal shedding occurred. An immunohistochemistry test on formalin-fixed ear notches and an antigen-capture enzyme-linked immunosorbent assay on fresh notches in phosphate-buffered saline did not detect BVDV antigen in any of the acutely or transiently infected calves, whereas both tests had positive results in all the PI calves.

Les veaux infectés de manière persistante (PI) avec le virus de la diarrhée virale bovine (BVDV) représentent une source d’infection importante pour les bovins susceptibles. L’efficacité d’un vaccin a été évaluée en utilisant des veaux PI avec une souche non-cytopathogène de BVDV2a pour les infections défis et des épreuves comparées pour détecter le BVDV chez des veaux infectés de manière aigue ou transitoire et les comparés à des veaux PI. Une vaccination avec 2 doses du vaccin vivant modifié contenant BVDV1a et BVDV2a protégeait les veaux exposés aux veaux PI; aucune virémie ou excrétion virale n’ont été détectées. Une épreuve immuno-histochimique sur des tissus d’oreille fixés dans la formaline et une épreuve immuno-enzymatique de capture d’antigène sur des morceaux d’oreille frais dans de la saline tamponnée n’ont pas permis de mettre en évidence du BVDV dans aucun des veaux infectés de manière aigue ou transitoire, alors que chez les veaux PI les deux épreuves ont donné des résultats positifs.

(Traduit par Docteur Serge Messier)

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