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. 2006 May 4;49(9):2677-80.
doi: 10.1021/jm051225t.

Identification of type 1 inosine monophosphate dehydrogenase as an antiangiogenic drug target

Curtis R Chong  1 , David Z Qian, Fan Pan, Yongfeng Wei, Roberto Pili, David J Sullivan Jr, Jun O Liu
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Identification of type 1 inosine monophosphate dehydrogenase as an antiangiogenic drug target

Curtis R Chong et al. J Med Chem. .

Abstract

To rapidly discover clinically useful angiogenesis inhibitors, we created and screened a library of existing drugs for inhibition of endothelial cell proliferation. Mycophenolic acid (MPA), an immunosuppressive drug, was found to potently inhibit endothelial cell proliferation in vitro and block tumor-induced angiogenesis in vivo. Using RNA interference, we found that knockdown of one of the two known isoforms of inosine monophosphate dehydrogenase (IMPDH-1) is sufficient to cause endothelial cell cycle arrest.

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