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. 2006 May;50(5):1859-60.
doi: 10.1128/AAC.50.5.1859-1860.2006.

Curcumin-artemisinin combination therapy for malaria

Dalavaikodihalli Nanjaiah Nandakumar  1 , Viswanathan Arun Nagaraj, Palakkod Govindan Vathsala, Pundi Rangarajan, Govindarajan Padmanaban
Affiliations

Curcumin-artemisinin combination therapy for malaria

Dalavaikodihalli Nanjaiah Nandakumar et al. Antimicrob Agents Chemother. 2006 May.

Abstract

Artemisinin and curcumin show an additive interaction in killing Plasmodium falciparum in culture. In vivo, 3 oral doses of curcumin following a single injection of alpha,beta-arteether to Plasmodium berghei-infected mice are able to prevent recrudescence due to alpha,beta-arteether monotherapy and ensure almost 100% survival of the animals.

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Figures

FIG. 1.
FIG. 1.
Effect of curcumin and arteether on mortality of P. berghei-infected mice.
See this image and copyright information in PMC

References

    1. Cheng, A. L., J. K. Hsu, M. Lin, Y. F. Hsu, T. S. Ho, J. Y. Shen, J. T. Ko, B. R. Lin, W. Lin, H. S. Ming-Shiang, et al. 2001. Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high risk or premalignant lesion. Anticancer Res. 21:2895-2900. - PubMed
    1. Desjardins, R. E., R. E. Canefield, C. J. Hayness, and J. D. Chulay. 1979. Quantitative assessment of antimalarial activity in vitro by semiautomated microdilution technique. Antimicrob. Agents Chemother. 16:710-718. - PMC - PubMed
    1. Fitch, C. D., R. Chevli, H. S. Banyal, G. Phillips, M. A. Pfaller, and D. J. Krogstad. 1982. Lysis of Plasmodium falciparum by ferriprotoporpyrin IX and chloroquine-ferriprotoporphyrin IX complex. Antimicrob. Agents Chemother. 21:819-822. - PMC - PubMed
    1. International Artemisinin Study Group. 2004. Artesunate combination for treatment of malaria: meta-analysis. Lancet 363:9-17. - PubMed
    1. Jambou, R., E. Legrand, M. Niang, N. Khim, P. Lim, B. Volney, M. T. Ekala, C. Bouchier, P. Esterre, T. Fandeur, and O. Mercereau-Puijalon. 2005. Resistance of Plasmodium falciparum field isolates to in vitro artemeether and point mutations of the SERCA-type PfATPase 6. Lancet 366:1960-1963. - PubMed

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