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Comparative Study
. 2006 May;50(5):1878-80.
doi: 10.1128/AAC.50.5.1878-1880.2006.

Intrapulmonary penetration of voriconazole in patients receiving an oral prophylactic regimen

Blair Capitano  1 , Brian A Potoski, Shahid Husain, Shimin Zhang, David L Paterson, Sean M Studer, Kenneth R McCurry, Raman Venkataramanan
Affiliations
Comparative Study

Intrapulmonary penetration of voriconazole in patients receiving an oral prophylactic regimen

Blair Capitano et al. Antimicrob Agents Chemother. 2006 May.

Abstract

Voriconazole penetrated well into the pulmonary epithelial lining fluid (ELF) in lung transplant patients receiving oral prophylaxis. The ELF concentrations exceeded those of the plasma, with an average ELF-to-plasma ratio of 11 (+/-8). A strong association between plasma and ELF concentrations (r(2) = 0.95) was noted.

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References

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