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Randomized Controlled Trial
. 2006 May;50(5):1881-3.
doi: 10.1128/AAC.50.5.1881-1883.2006.

Effect of a nutritional supplement on posaconazole pharmacokinetics following oral administration to healthy volunteers

Angela Sansone-Parsons  1 , Gopal Krishna, Angela Calzetta, David Wexler, Bhavna Kantesaria, Mitchell A Rosenberg, Marc A Saltzman
Affiliations
Randomized Controlled Trial

Effect of a nutritional supplement on posaconazole pharmacokinetics following oral administration to healthy volunteers

Angela Sansone-Parsons et al. Antimicrob Agents Chemother. 2006 May.

Abstract

We conducted a randomized, crossover study in healthy adults to examine the effects of a nutritional supplement (Boost Plus) on posaconazole pharmacokinetics. In this study, coadministration of posaconazole with Boost Plus increased the maximum concentration of posaconazole in serum and area under the concentration-time curve from 0 to 72 h values 3.4- and 2.6-fold, respectively, compared to those for the fasted state.

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Figures

FIG. 1.
FIG. 1.
Log-linear mean plasma concentration-time profiles of posaconazole under fasted conditions or when coadministered with Boost Plus. Each vertical bar represents 1 standard deviation from the mean.
See this image and copyright information in PMC

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